CORRELATION BETWEEN TPC AND TFC WITH ANTIOXIDANT ACTIVITY OF Piper sarmentosum EXTRACT AND ITS FORMULATION FOR COSMETIC PURPOSES

This study investigates the characteristics of an antioxidant cream made from methanol extract Piper sarmentosum leaves, which is locally known as wild betel or pokok kadok in Malay. The secondary metabolites leaves were subjected to phytochemical tests detect presence natural compounds. Antioxidant activity was described by its total phenolic content (TPC) and flavonoid (TFC), assessed 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay. A phase diagram constructed find a possible region formulate cream. In screening, methanolic showed positive alkaloids, flavonoids, steroids, terpenoids tannins. quantitative analysis antioxidative components, besides having significantly higher TFC compared with quercetin (P<0.0001), P. also displayed high proven be efficient free radical scavenger reducing agent ascorbic acid (p=0.0121). It observed that compounds leaf like terpenoids, flavonoids tannins major contributors activity. suitable ingredient produce good spreadability, homogeneity, consistency, appearance pH.